应用文章
Microtubules are long, hollow, stiff polymers that extend throughout the cell cytoplasm. They are involved in diverse functions that range from governing the location of membrane-bounded organelles to chromosome separation during mitosis. The basic structural unit of a microtubule is tubulin, which is a heterodimer consisting of two closely related and tightly linked globular polypeptides called a- and b-tubulin. Alternating a- and b-tubulin subunits form protofilaments, thirteen of which bundle around a central core to form a microtubule. The detailed structures of cytoplasmic microtubules have been studied extensively using various electron microscopy techniques (see Figure 1).
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