应用文章
Introduction
Biological molecules can be attached to silicon and silicon nitride AFM probes, transforming them into sensitive, nanoscale, biochemically selective sensors. The biochemically modified AFM probes can be used to study single molecule interactions in various AFM-based techniques. One such AFM-based method that relies on the biochemically modified AFM probes is a force spectroscopy (FS) technique called molecular recognition force microscopy (MRFM) [Riener 2003, Hinterdorfer 2004]. In MRFM, distinct interactions between even just one ligand molecule, which is immobilized on the tip of the AFM probe, and complimentary receptor molecules, which are immobilized on an opposing substrate, can be investigated one by one as the biochemically modified AFM probe first approaches and then is subsequently withdrawn away from the substrate.
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